Omeprazole ameliorates aspirin-induced gastroduodenal injury
نویسندگان
چکیده
منابع مشابه
Influence of Helicobacter pylori and omeprazole on celecoxib-induced gastroduodenal mucosal injury.
A recent study involving about 8500 patients showed that patients receiving proton pump inhibitors with both selective and nonselective NSAIDs had more upper GI events, when compared to those receiving histamine H2 blockers, misoprostol, antacids, or sucralfate.1 Helicobacter pylori has been shown to augment the acid-suppressing effect of omeprazole.2 Available data fail to give clear guideline...
متن کاملAbolition by omeprazole of aspirin induced gastric
This study investigates whether aspirin injury to the human gastric mucosa can be prevented by profound acid suppression with omeprazole, in a randomised, double blind, crossover design according to latin square. It was concluded that profound acid suppression can prevent aspirin induced gastric mucosal injury in normal subjects. This approach may prevent the development of peptic ulcers and th...
متن کاملElfect of allopurinol, sulphasalazine, and vitamin C on aspirin induced gastroduodenal injury in human volunteers
on prostanoids was determined by measuring ex vivo antral prostaglandin E2 (PGE2) synthesis and serum thromboxane B2 (TXB2). Results-No drug reduced any parameter of gastric injury but vitamin C reduced duodenal injury assessed by Lanza score (p<0.005). Chemiluminescence increased after aspirin both with placebo (p<0.05) and vitamin C (p<005). Post-treatment chemiluminescence was lower in subje...
متن کاملLow-dose aspirin-induced gastroduodenal mucosal injury in Japanese patients with arteriosclerotic disease.
BACKGROUND We aimed to elucidate the risk factors and preventive factors associated with chronic low-dose aspirin (L-ASA)-induced gastroduodenal mucosal injury in Japanese patients with arteriosclerotic disease. METHODS This retrospective observational study included 400 L-ASA users who underwent upper gastrointestinal endoscopy. We investigated patients' clinical characteristics, including a...
متن کاملEffect of allopurinol, sulphasalazine, and vitamin C on aspirin induced gastroduodenal injury in human volunteers.
BACKGROUND The mechanisms of aspirin induced gastroduodenal injury are not fully understood. Aspirin induces the release of reactive oxygen metabolites in animal models, which may contribute to mucosal injury. AIMS To investigate the effects of aspirin administered with placebo or antioxidants on gastric mucosal reactive oxygen metabolite release and gastroduodenal injury in human volunteers....
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ژورنال
عنوان ژورنال: Digestive Diseases and Sciences
سال: 1994
ISSN: 0163-2116,1573-2568
DOI: 10.1007/bf02090067